What is FNAIT?

Foetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) is a rare but potentially very serious condition that occurs in about 1 out of 2,000 pregnancies. The condition is characterized by destruction of blood platelets in foetuses and newborns due to maternal antibodies that have traversed placenta.

The foetus or newborn becomes thrombocytopenic and is at risk of intracranial hemorrhage that may result in lifelong disability or death. Currently no satisfactory preventive measures or treatment exist for this rare but potentially life-threatening condition.

FNAIT is most commonly caused by incompatibility between mother and fetus for the Human Platelet Antigen-1a (HPA-1a).


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